SSRI / 5-HT1A Partial Agonist AntidepressantConditionally Approved

Vilazodone

Brand names: Viibryd|Last verified: 2026-09-12

FAA Pathway: Special Issuance (FAA Antidepressant Protocol); HIMS AME evaluation required

Vilazodone (Viibryd) is one of nine conditionally acceptable antidepressants under the FAA's Antidepressant Protocol (formerly the SSRI Protocol). The AME cannot issue your first certificate; the FAA decides case by case through Special Issuance. You must be stable on the same dose for at least 3 continuous months without aeromedically significant side effects, take it as your only antidepressant, and be evaluated by a HIMS AME.

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Pilot Tip

Always report all medications on your FAA medical application (Form 8500-8, Item 17a), even OTC medications. Failure to disclose is a far bigger issue than the medication itself.

Certification Details

FAA Status

Conditionally acceptable with Special Issuance (FAA Antidepressant Medications table)

Stability Period

At least 3 continuous months on a stable dose, clinically stable, with no aeromedically significant side effects

Monotherapy

Single agent only — not combined with other antidepressants or psychiatric medications

Initial Evaluation

HIMS AME face-to-face evaluation, board-certified psychiatrist report, and neuropsychological testing including CogScreen-AE

Follow-Up

HIMS AME evaluation and psychiatrist report every 6 months

Certificate Classes

1st, 2nd, and 3rd class via Special Issuance

Sources

FAA AME Guide — Pharmaceuticals: Antidepressant Medications (faa.gov/ame_guide/media/Antidepressant_Medications.pdf)
FAA AME Guide — Item 47: Use of Antidepressant Medications (faa.gov/ame_guide/app_process/exam_tech/item47/amd/antidepressants)

Last verified: 2026-09-12

Frequently Asked Questions

Is Vilazodone allowed for pilots?

The FAA considers Vilazodone (Viibryd) to be "Conditionally Approved" for medical certification purposes. Vilazodone (Viibryd) is one of nine conditionally acceptable antidepressants under the FAA's Antidepressant Protocol (formerly the SSRI Protocol). The AME cannot issue your first certificate; the FAA decides case by case through Special Issuance. You must be stable on the same dose for at least 3 continuous months without aeromedically significant side effects, take it as your only antidepressant, and be evaluated by a HIMS AME.

What is the FAA status of Vilazodone?

Vilazodone has a status of "Conditionally Approved" under FAA medical certification policy. The certification pathway is: Special Issuance (FAA Antidepressant Protocol); HIMS AME evaluation required.

Can I fly while taking Vilazodone?

Flying while taking Vilazodone may be possible through the FAA's Special Issuance process. You will need to meet specific requirements and obtain approval before exercising pilot privileges. Consult an experienced AME for guidance.

Important Notice

The FAA does not publish a comprehensive list of “approved” medications. The information on this page represents our interpretation of publicly available FAA guidance and is provided for informational and educational purposes only. It does not constitute medical advice, legal advice, or a guarantee of certification outcome.

The primary issue with the FAA is always whether the underlying medical condition — not just the medication — is compatible with safe flight. You should only start, stop, or change medications after consulting your treating physician. Always consult with a qualified Aviation Medical Examiner (AME) for guidance specific to your situation. FAA policies are subject to change. ClearedMed is not affiliated with or endorsed by the FAA.