Thiazolidinedione (Type 2 Diabetes)Generally Approved

Pioglitazone

Brand names: Actos|Last verified: 2026-03-01

FAA Pathway: Standard issuance by AME for well-controlled Type 2 diabetes

Pioglitazone is a thiazolidinedione approved for FAA certification when used for Type 2 diabetes. Low hypoglycemia risk as monotherapy. Report on your application with diabetes documentation.

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Pilot Tip

Always report all medications on your FAA medical application (Form 8500-8, Item 17a), even OTC medications. Failure to disclose is a far bigger issue than the medication itself.

Certification Details

Key Requirements

A1C controlled, no edema or heart failure symptoms

Certificate Classes

All classes eligible

Side Effects to Report

Edema, weight gain, visual changes

Notes

Contraindicated with heart failure — underlying condition matters

Sources

FAA AME Guide — Pharmaceuticals: Diabetes Type II (faa.gov/ame_guide/pharm/oral_diabetes)

Last verified: 2026-03-01

Frequently Asked Questions

Is Pioglitazone allowed for pilots?

The FAA considers Pioglitazone (Actos) to be "Generally Approved" for medical certification purposes. Pioglitazone is a thiazolidinedione approved for FAA certification when used for Type 2 diabetes. Low hypoglycemia risk as monotherapy. Report on your application with diabetes documentation.

What is the FAA status of Pioglitazone?

Pioglitazone has a status of "Generally Approved" under FAA medical certification policy. The certification pathway is: Standard issuance by AME for well-controlled Type 2 diabetes.

Can I fly while taking Pioglitazone?

Pioglitazone is generally compatible with flying. However, you must report it on your FAA medical application (Form 8500-8) and ensure you are not experiencing side effects that could impair flight safety. Always consult your Aviation Medical Examiner (AME).

Important Notice

The FAA does not publish a comprehensive list of “approved” medications. The information on this page represents our interpretation of publicly available FAA guidance and is provided for informational and educational purposes only. It does not constitute medical advice, legal advice, or a guarantee of certification outcome.

The primary issue with the FAA is always whether the underlying medical condition — not just the medication — is compatible with safe flight. You should only start, stop, or change medications after consulting your treating physician. Always consult with a qualified Aviation Medical Examiner (AME) for guidance specific to your situation. FAA policies are subject to change. ClearedMed is not affiliated with or endorsed by the FAA.