Methotrexate
Brand names: Trexall, Rheumatrex|Last verified: 2026-03-01
FAA Pathway: Special Issuance — depends on underlying condition
Methotrexate may be conditionally approved depending on the underlying autoimmune condition. Used for rheumatoid arthritis and psoriasis, the medication requires monitoring but is not specifically on the DNI list. The underlying condition drives the pathway.
Related Resources
Pilot Tip
Always report all medications on your FAA medical application (Form 8500-8, Item 17a), even OTC medications. Failure to disclose is a far bigger issue than the medication itself.
Certification Details
Sources
- FAA AME Guide, Rheumatology
Last verified: 2026-03-01
Frequently Asked Questions
Is Methotrexate allowed for pilots?
The FAA considers Methotrexate (Trexall, Rheumatrex) to be "Conditionally Approved" for medical certification purposes. Methotrexate may be conditionally approved depending on the underlying autoimmune condition. Used for rheumatoid arthritis and psoriasis, the medication requires monitoring but is not specifically on the DNI list. The underlying condition drives the pathway.
What is the FAA status of Methotrexate?
Methotrexate has a status of "Conditionally Approved" under FAA medical certification policy. The certification pathway is: Special Issuance — depends on underlying condition.
Can I fly while taking Methotrexate?
Flying while taking Methotrexate may be possible through the FAA's Special Issuance process. You will need to meet specific requirements and obtain approval before exercising pilot privileges. Consult an experienced AME for guidance.
Important Notice
The FAA does not publish a comprehensive list of “approved” medications. The information on this page represents our interpretation of publicly available FAA guidance and is provided for informational and educational purposes only. It does not constitute medical advice, legal advice, or a guarantee of certification outcome.
The primary issue with the FAA is always whether the underlying medical condition — not just the medication — is compatible with safe flight. You should only start, stop, or change medications after consulting your treating physician. Always consult with a qualified Aviation Medical Examiner (AME) for guidance specific to your situation. FAA policies are subject to change. ClearedMed is not affiliated with or endorsed by the FAA.