Mefloquine
Brand names: Lariam|Last verified: 2026-09-12
FAA Pathway: Do Not Issue (DNI) — must be discontinued at least 4 weeks before FAA consideration
The FAA considers mefloquine (Lariam) absolutely disqualifying for pilots because it can cause neuropsychiatric side effects even weeks after you stop taking it. It must be discontinued for at least 4 weeks before consideration, you must contact an FAA flight surgeon or your AME before resuming pilot duties, and you must have had no neurologic or psychiatric symptoms during or after use. Most other malaria medications are allowed.
Related Resources
Pilot Tip
Always report all medications on your FAA medical application (Form 8500-8, Item 17a), even OTC medications. Failure to disclose is a far bigger issue than the medication itself.
Certification Details
Sources
- FAA Do-Not-Issue/Do-Not-Fly Table (faa.gov/ame_guide/media/DNI_DNF_tables.pdf)
- FAA AME Guide — Pharmaceuticals: Malaria (faa.gov/ame_guide/pharm/malaria)
Last verified: 2026-09-12
Frequently Asked Questions
Is Mefloquine allowed for pilots?
The FAA considers Mefloquine (Lariam) to be "Disqualifying" for medical certification purposes. The FAA considers mefloquine (Lariam) absolutely disqualifying for pilots because it can cause neuropsychiatric side effects even weeks after you stop taking it. It must be discontinued for at least 4 weeks before consideration, you must contact an FAA flight surgeon or your AME before resuming pilot duties, and you must have had no neurologic or psychiatric symptoms during or after use. Most other malaria medications are allowed.
What is the FAA status of Mefloquine?
Mefloquine has a status of "Disqualifying" under FAA medical certification policy. The certification pathway is: Do Not Issue (DNI) — must be discontinued at least 4 weeks before FAA consideration.
Can I fly while taking Mefloquine?
Mefloquine is currently disqualifying for FAA medical certification. You cannot fly while taking this medication. A washout period and evaluation are typically required after discontinuation. Consult an AME or aviation attorney before making any medication changes.
Important Notice
The FAA does not publish a comprehensive list of “approved” medications. The information on this page represents our interpretation of publicly available FAA guidance and is provided for informational and educational purposes only. It does not constitute medical advice, legal advice, or a guarantee of certification outcome.
The primary issue with the FAA is always whether the underlying medical condition — not just the medication — is compatible with safe flight. You should only start, stop, or change medications after consulting your treating physician. Always consult with a qualified Aviation Medical Examiner (AME) for guidance specific to your situation. FAA policies are subject to change. ClearedMed is not affiliated with or endorsed by the FAA.