GI Agent (IBS-C / Chronic Constipation)Generally Approved

Linaclotide

Brand names: Linzess|Last verified: 2026-03-01

FAA Pathway: Standard issuance by AME

Linaclotide for IBS with constipation is generally compatible with FAA certification. The medication acts locally in the gut with minimal systemic absorption. Report the underlying condition on your application.

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Pilot Tip

Always report all medications on your FAA medical application (Form 8500-8, Item 17a), even OTC medications. Failure to disclose is a far bigger issue than the medication itself.

Certification Details

Key Requirements

IBS symptoms well-controlled, no incapacitating episodes

Certificate Classes

All classes eligible

Notes

Minimal systemic absorption — acts locally

Sources

FAA AME Guide, Pharmaceuticals

Last verified: 2026-03-01

Frequently Asked Questions

Is Linaclotide allowed for pilots?

The FAA considers Linaclotide (Linzess) to be "Generally Approved" for medical certification purposes. Linaclotide for IBS with constipation is generally compatible with FAA certification. The medication acts locally in the gut with minimal systemic absorption. Report the underlying condition on your application.

What is the FAA status of Linaclotide?

Linaclotide has a status of "Generally Approved" under FAA medical certification policy. The certification pathway is: Standard issuance by AME.

Can I fly while taking Linaclotide?

Linaclotide is generally compatible with flying. However, you must report it on your FAA medical application (Form 8500-8) and ensure you are not experiencing side effects that could impair flight safety. Always consult your Aviation Medical Examiner (AME).

Important Notice

The FAA does not publish a comprehensive list of “approved” medications. The information on this page represents our interpretation of publicly available FAA guidance and is provided for informational and educational purposes only. It does not constitute medical advice, legal advice, or a guarantee of certification outcome.

The primary issue with the FAA is always whether the underlying medical condition — not just the medication — is compatible with safe flight. You should only start, stop, or change medications after consulting your treating physician. Always consult with a qualified Aviation Medical Examiner (AME) for guidance specific to your situation. FAA policies are subject to change. ClearedMed is not affiliated with or endorsed by the FAA.