Levocetirizine
Brand names: Xyzal|Last verified: 2026-09-12
FAA Pathway: Occasional use only (1–2 times a week) — 48-hour no-fly after each dose
The FAA classifies levocetirizine (Xyzal) as a sedating second-generation antihistamine. It is conditionally acceptable: you may use it occasionally (1–2 times a week), but daily use is not acceptable, and you must not fly for 48 hours after each dose. Loratadine (Claritin), fexofenadine (Allegra), and desloratadine (Clarinex) are acceptable without a post-dose wait.
Related Resources
Pilot Tip
Always report all medications on your FAA medical application (Form 8500-8, Item 17a), even OTC medications. Failure to disclose is a far bigger issue than the medication itself.
Certification Details
Sources
- FAA AME Guide — Pharmaceuticals: Allergy – Antihistamine & Immunotherapy (faa.gov/ame_guide/media/AllergyAntihistamineImmunotherapyMedication.pdf)
- FAA Pilot OTC Medications Reference Guide (faa.gov/pilots/medical_certification/media/OTCMedicationsforPilots.pdf)
Last verified: 2026-09-12
Frequently Asked Questions
Is Levocetirizine allowed for pilots?
The FAA considers Levocetirizine (Xyzal) to be "Conditionally Approved" for medical certification purposes. The FAA classifies levocetirizine (Xyzal) as a sedating second-generation antihistamine. It is conditionally acceptable: you may use it occasionally (1–2 times a week), but daily use is not acceptable, and you must not fly for 48 hours after each dose. Loratadine (Claritin), fexofenadine (Allegra), and desloratadine (Clarinex) are acceptable without a post-dose wait.
What is the FAA status of Levocetirizine?
Levocetirizine has a status of "Conditionally Approved" under FAA medical certification policy. The certification pathway is: Occasional use only (1–2 times a week) — 48-hour no-fly after each dose.
Can I fly while taking Levocetirizine?
Flying while taking Levocetirizine may be possible through the FAA's Special Issuance process. You will need to meet specific requirements and obtain approval before exercising pilot privileges. Consult an experienced AME for guidance.
Important Notice
The FAA does not publish a comprehensive list of “approved” medications. The information on this page represents our interpretation of publicly available FAA guidance and is provided for informational and educational purposes only. It does not constitute medical advice, legal advice, or a guarantee of certification outcome.
The primary issue with the FAA is always whether the underlying medical condition — not just the medication — is compatible with safe flight. You should only start, stop, or change medications after consulting your treating physician. Always consult with a qualified Aviation Medical Examiner (AME) for guidance specific to your situation. FAA policies are subject to change. ClearedMed is not affiliated with or endorsed by the FAA.