SNRI AntidepressantConditionally Approved

Duloxetine

Brand names: Cymbalta|Last verified: 2026-09-12

FAA Pathway: Special Issuance (FAA Antidepressant Protocol); HIMS AME evaluation required

Duloxetine (Cymbalta) is one of the FAA's conditionally acceptable antidepressants under the Antidepressant Protocol (formerly the SSRI Protocol), which added SNRIs on April 24, 2024. The AME cannot issue; the FAA decides case by case through Special Issuance. You must be stable on the same dose for at least 3 continuous months without aeromedically significant side effects, take it as your only antidepressant, and be evaluated by a HIMS AME.

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Pilot Tip

Always report all medications on your FAA medical application (Form 8500-8, Item 17a), even OTC medications. Failure to disclose is a far bigger issue than the medication itself.

Certification Details

FAA Status

Conditionally acceptable with Special Issuance (FAA Antidepressant Medications table)

Stability Period

At least 3 continuous months on a stable dose, clinically stable, with no aeromedically significant side effects

Monotherapy

Single agent only — not combined with other antidepressants or psychiatric medications

Evaluation

HIMS AME evaluation and neuropsychological testing per FAA specifications

Disqualifying History

Psychosis, suicidal ideation, electroconvulsive therapy, or treatment with multiple antidepressants at once

Other Uses

May also be considered when used for a non-depression condition (such as pain), but that underlying condition is reviewed too

Certificate Classes

1st, 2nd, and 3rd class via Special Issuance

Sources

FAA AME Guide — Pharmaceuticals: Antidepressant Medications (faa.gov/ame_guide/media/Antidepressant_Medications.pdf)

Last verified: 2026-09-12

Frequently Asked Questions

Is Duloxetine allowed for pilots?

The FAA considers Duloxetine (Cymbalta) to be "Conditionally Approved" for medical certification purposes. Duloxetine (Cymbalta) is one of the FAA's conditionally acceptable antidepressants under the Antidepressant Protocol (formerly the SSRI Protocol), which added SNRIs on April 24, 2024. The AME cannot issue; the FAA decides case by case through Special Issuance. You must be stable on the same dose for at least 3 continuous months without aeromedically significant side effects, take it as your only antidepressant, and be evaluated by a HIMS AME.

What is the FAA status of Duloxetine?

Duloxetine has a status of "Conditionally Approved" under FAA medical certification policy. The certification pathway is: Special Issuance (FAA Antidepressant Protocol); HIMS AME evaluation required.

Can I fly while taking Duloxetine?

Flying while taking Duloxetine may be possible through the FAA's Special Issuance process. You will need to meet specific requirements and obtain approval before exercising pilot privileges. Consult an experienced AME for guidance.

Important Notice

The FAA does not publish a comprehensive list of “approved” medications. The information on this page represents our interpretation of publicly available FAA guidance and is provided for informational and educational purposes only. It does not constitute medical advice, legal advice, or a guarantee of certification outcome.

The primary issue with the FAA is always whether the underlying medical condition — not just the medication — is compatible with safe flight. You should only start, stop, or change medications after consulting your treating physician. Always consult with a qualified Aviation Medical Examiner (AME) for guidance specific to your situation. FAA policies are subject to change. ClearedMed is not affiliated with or endorsed by the FAA.