Tricyclic Antidepressant / Sleep AidDisqualifying

Doxepin

Brand names: Sinequan, Silenor|Last verified: 2026-03-01

FAA Pathway: Do Not Issue (DNI) list

Doxepin is on the FAA's DNI list. Whether used at antidepressant doses (Sinequan) or low doses for insomnia (Silenor), it is disqualifying. All tricyclic antidepressants are incompatible with aviation.

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Pilot Tip

Always report all medications on your FAA medical application (Form 8500-8, Item 17a), even OTC medications. Failure to disclose is a far bigger issue than the medication itself.

Certification Details

FAA Status

Do Not Issue (DNI) list — all TCAs

Low-Dose Sleep Use

Even Silenor (low-dose for sleep) is disqualifying

Certificate Classes

All classes affected

Notes

Significant sedation at all dose levels

Sources

FAA Do Not Issue Table

Last verified: 2026-03-01

Frequently Asked Questions

Is Doxepin allowed for pilots?

The FAA considers Doxepin (Sinequan, Silenor) to be "Disqualifying" for medical certification purposes. Doxepin is on the FAA's DNI list. Whether used at antidepressant doses (Sinequan) or low doses for insomnia (Silenor), it is disqualifying. All tricyclic antidepressants are incompatible with aviation.

What is the FAA status of Doxepin?

Doxepin has a status of "Disqualifying" under FAA medical certification policy. The certification pathway is: Do Not Issue (DNI) list.

Can I fly while taking Doxepin?

Doxepin is currently disqualifying for FAA medical certification. You cannot fly while taking this medication. A washout period and evaluation are typically required after discontinuation. Consult an AME or aviation attorney before making any medication changes.

Important Notice

The FAA does not publish a comprehensive list of “approved” medications. The information on this page represents our interpretation of publicly available FAA guidance and is provided for informational and educational purposes only. It does not constitute medical advice, legal advice, or a guarantee of certification outcome.

The primary issue with the FAA is always whether the underlying medical condition — not just the medication — is compatible with safe flight. You should only start, stop, or change medications after consulting your treating physician. Always consult with a qualified Aviation Medical Examiner (AME) for guidance specific to your situation. FAA policies are subject to change. ClearedMed is not affiliated with or endorsed by the FAA.