Antiarrhythmic (Class III)Conditionally Approved

Dofetilide

Brand names: Tikosyn|Last verified: 2026-03-01

FAA Pathway: Special Issuance required — cardiac evaluation mandatory

Dofetilide requires Special Issuance evaluation. Used for atrial fibrillation and atrial flutter, the underlying arrhythmia and the medication's QT-prolonging potential both require thorough cardiac evaluation and monitoring.

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Pilot Tip

Always report all medications on your FAA medical application (Form 8500-8, Item 17a), even OTC medications. Failure to disclose is a far bigger issue than the medication itself.

Certification Details

Key Requirements

Cardiac evaluation, QT interval monitoring, electrolyte stability

Certificate Classes

May be eligible with extensive cardiac documentation

Monitoring

Regular ECG, electrolyte surveillance, renal function

Notes

Must be initiated in hospital setting; strict monitoring required

Sources

FAA AME Guide, Cardiology

Last verified: 2026-03-01

Frequently Asked Questions

Is Dofetilide allowed for pilots?

The FAA considers Dofetilide (Tikosyn) to be "Conditionally Approved" for medical certification purposes. Dofetilide requires Special Issuance evaluation. Used for atrial fibrillation and atrial flutter, the underlying arrhythmia and the medication's QT-prolonging potential both require thorough cardiac evaluation and monitoring.

What is the FAA status of Dofetilide?

Dofetilide has a status of "Conditionally Approved" under FAA medical certification policy. The certification pathway is: Special Issuance required — cardiac evaluation mandatory.

Can I fly while taking Dofetilide?

Flying while taking Dofetilide may be possible through the FAA's Special Issuance process. You will need to meet specific requirements and obtain approval before exercising pilot privileges. Consult an experienced AME for guidance.

Important Notice

The FAA does not publish a comprehensive list of “approved” medications. The information on this page represents our interpretation of publicly available FAA guidance and is provided for informational and educational purposes only. It does not constitute medical advice, legal advice, or a guarantee of certification outcome.

The primary issue with the FAA is always whether the underlying medical condition — not just the medication — is compatible with safe flight. You should only start, stop, or change medications after consulting your treating physician. Always consult with a qualified Aviation Medical Examiner (AME) for guidance specific to your situation. FAA policies are subject to change. ClearedMed is not affiliated with or endorsed by the FAA.