Bupropion-Naltrexone
Brand names: Contrave|Last verified: 2026-09-12
FAA Pathway: Do Not Issue (DNI) — weight loss medication
Bupropion-naltrexone (Contrave) is on the FAA's Do Not Issue list and is listed as an unacceptable weight loss medication. An AME cannot issue a medical certificate while you are taking it. Bupropion alone in SR/ER form is handled differently, under the FAA's Antidepressant Protocol.
Related Resources
Pilot Tip
Always report all medications on your FAA medical application (Form 8500-8, Item 17a), even OTC medications. Failure to disclose is a far bigger issue than the medication itself.
Certification Details
Sources
- FAA Do-Not-Issue/Do-Not-Fly Table (faa.gov/ame_guide/media/DNI_DNF_tables.pdf)
- FAA AME Guide — Pharmaceuticals: Weight Loss (faa.gov/ame_guide/media/Weight_loss_pharm.pdf)
Last verified: 2026-09-12
Frequently Asked Questions
Is Bupropion-Naltrexone allowed for pilots?
The FAA considers Bupropion-Naltrexone (Contrave) to be "Disqualifying" for medical certification purposes. Bupropion-naltrexone (Contrave) is on the FAA's Do Not Issue list and is listed as an unacceptable weight loss medication. An AME cannot issue a medical certificate while you are taking it. Bupropion alone in SR/ER form is handled differently, under the FAA's Antidepressant Protocol.
What is the FAA status of Bupropion-Naltrexone?
Bupropion-Naltrexone has a status of "Disqualifying" under FAA medical certification policy. The certification pathway is: Do Not Issue (DNI) — weight loss medication.
Can I fly while taking Bupropion-Naltrexone?
Bupropion-Naltrexone is currently disqualifying for FAA medical certification. You cannot fly while taking this medication. A washout period and evaluation are typically required after discontinuation. Consult an AME or aviation attorney before making any medication changes.
Important Notice
The FAA does not publish a comprehensive list of “approved” medications. The information on this page represents our interpretation of publicly available FAA guidance and is provided for informational and educational purposes only. It does not constitute medical advice, legal advice, or a guarantee of certification outcome.
The primary issue with the FAA is always whether the underlying medical condition — not just the medication — is compatible with safe flight. You should only start, stop, or change medications after consulting your treating physician. Always consult with a qualified Aviation Medical Examiner (AME) for guidance specific to your situation. FAA policies are subject to change. ClearedMed is not affiliated with or endorsed by the FAA.