Bupropion
Brand names: Wellbutrin, Zyban|Last verified: 2026-03-01
FAA Pathway: Do Not Issue (DNI) list — not an approved SSRI
Bupropion is on the FAA's Do Not Issue list. It is NOT one of the four approved SSRI antidepressants (sertraline, fluoxetine, citalopram, escitalopram). Bupropion is an NDRI with a different mechanism and seizure risk, and it does not qualify under the SSRI Special Issuance protocol.
Related Resources
Pilot Tip
Always report all medications on your FAA medical application (Form 8500-8, Item 17a), even OTC medications. Failure to disclose is a far bigger issue than the medication itself.
Certification Details
Sources
- FAA AME Guide — Pharmaceuticals: Antidepressants (faa.gov/ame_guide/pharm/antidepressants)
- FAA DNI/DNF Table (faa.gov/ame_guide/pharm/dni_dnf)
Last verified: 2026-03-01
Frequently Asked Questions
Is Bupropion allowed for pilots?
The FAA considers Bupropion (Wellbutrin, Zyban) to be "Disqualifying" for medical certification purposes. Bupropion is on the FAA's Do Not Issue list. It is NOT one of the four approved SSRI antidepressants (sertraline, fluoxetine, citalopram, escitalopram). Bupropion is an NDRI with a different mechanism and seizure risk, and it does not qualify under the SSRI Special Issuance protocol.
What is the FAA status of Bupropion?
Bupropion has a status of "Disqualifying" under FAA medical certification policy. The certification pathway is: Do Not Issue (DNI) list — not an approved SSRI.
Can I fly while taking Bupropion?
Bupropion is currently disqualifying for FAA medical certification. You cannot fly while taking this medication. A washout period and evaluation are typically required after discontinuation. Consult an AME or aviation attorney before making any medication changes.
Important Notice
The FAA does not publish a comprehensive list of “approved” medications. The information on this page represents our interpretation of publicly available FAA guidance and is provided for informational and educational purposes only. It does not constitute medical advice, legal advice, or a guarantee of certification outcome.
The primary issue with the FAA is always whether the underlying medical condition — not just the medication — is compatible with safe flight. You should only start, stop, or change medications after consulting your treating physician. Always consult with a qualified Aviation Medical Examiner (AME) for guidance specific to your situation. FAA policies are subject to change. ClearedMed is not affiliated with or endorsed by the FAA.