Apremilast
Brand names: Otezla|Last verified: 2026-09-12
FAA Pathway: Acceptable if the underlying condition qualifies — 2-week ground trial, no post-dose wait
The FAA lists apremilast (Otezla) as an acceptable medication when used alone, as long as the underlying condition qualifies for certification — your diagnosis is what determines eligibility. You must complete a 2-week ground trial when starting and no wait is required after each dose. The FAA lists it among non-biologic medications in its biologics guidance.
Related Resources
Pilot Tip
Always report all medications on your FAA medical application (Form 8500-8, Item 17a), even OTC medications. Failure to disclose is a far bigger issue than the medication itself.
Certification Details
Sources
- FAA AME Guide — Pharmaceuticals: Biologics, Biosimilars, Non-Biologics (faa.gov/ame_guide/media/Biologics_Biosimilars_Non-Biologics.pdf)
Last verified: 2026-09-12
Frequently Asked Questions
Is Apremilast allowed for pilots?
The FAA considers Apremilast (Otezla) to be "Conditionally Approved" for medical certification purposes. The FAA lists apremilast (Otezla) as an acceptable medication when used alone, as long as the underlying condition qualifies for certification — your diagnosis is what determines eligibility. You must complete a 2-week ground trial when starting and no wait is required after each dose. The FAA lists it among non-biologic medications in its biologics guidance.
What is the FAA status of Apremilast?
Apremilast has a status of "Conditionally Approved" under FAA medical certification policy. The certification pathway is: Acceptable if the underlying condition qualifies — 2-week ground trial, no post-dose wait.
Can I fly while taking Apremilast?
Flying while taking Apremilast may be possible through the FAA's Special Issuance process. You will need to meet specific requirements and obtain approval before exercising pilot privileges. Consult an experienced AME for guidance.
Important Notice
The FAA does not publish a comprehensive list of “approved” medications. The information on this page represents our interpretation of publicly available FAA guidance and is provided for informational and educational purposes only. It does not constitute medical advice, legal advice, or a guarantee of certification outcome.
The primary issue with the FAA is always whether the underlying medical condition — not just the medication — is compatible with safe flight. You should only start, stop, or change medications after consulting your treating physician. Always consult with a qualified Aviation Medical Examiner (AME) for guidance specific to your situation. FAA policies are subject to change. ClearedMed is not affiliated with or endorsed by the FAA.